Postdoc position in transcription-coupled splicing at the MRC-LMB in Cambridge

Posted on April 19,

We are recruiting an enthusiastic Postdoctoral Scientist to work with Dr Suyang Zhang to investigate the mechanism of co-transcriptional alternative splicing. The aim is to understand the mechanism governing alternative splice site selection and the crosstalk between the transcription and splicing machineries. Our lab employs a multidisciplinary approach combining biochemical reconstitution, functional assays, and structural biology to define the molecular basis of transcription-coupled alternative splicing (Science 2021 371:6526).

Candidates must have a PhD in the biological sciences or be due to complete within 6 months and should have a strong background in biochemistry or cell biology. The candidate should have experience in mammalian suspension cell culture and cell line engineering (e.g. CRISPR/Cas9), while experience in isolation of native complexes would be advantageous. Previous experience in structural biology is not required. The candidate should have worked independently and, in a team, to have a significant track record, and to be committed and interested in interdisciplinary, collaborative work.

This position is funded by the MRC for 3 years. Applicants will be supported in getting independent fellowships. Applicants will be introduced to a professional development program that will help them for their future career and the group leader will provide support and mentorship.

Applicants should provide a CV, a motivation letter including a very brief description of current research activities and potential starting date, and contact information of 2 to 3 references.

Feel free to contact Dr Suyang Zhang for more information regarding the position: [email protected].

The successful applicant will be awarded a 3-year Career Development Fellowship/ Postdoctoral Training Scheme position. This is a training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. The MRC LMB has excellent scientific core facilities and training opportunities.

The MRC Laboratory of Molecular Biology is a research institute within UK Research and Innovation (UKRI). UKRI is an entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at

Working for UKRI MRC provides a whole host of benefits including a defined benefit pension scheme, excellent holiday entitlement (40 ½ days including bank holidays and privilege days) and Benenden Healthcare membership. You will also have access to employee shopping/ travel discounts, on site sport and social facilities, as well as a salary sacrifice scheme for cycle to work.

This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successful applicant is likely to be eligible to apply. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply).

Closing date: 03/05/2022