Research Associate– Immunology, in situ CAR

Posted on April 29,

Orna Therapeutics, Inc. is a Cambridge-based biotechnology startup on a mission to create therapies for diseases inaccessible to existing approaches. Built on novel circular RNA technology developed at MIT, Orna is leading the next wave of RNA therapeutics with our best-in-class expression and delivery platform. We are seeking an exceptional Research Associate to evaluate candidate cancer immunotherapies. The ideal candidate has a B.S degree in Immunology or a related field, with relevant in vitro and/or in vivo laboratory experience in executing assays to test gain-of-function (transgenes, gene therapy, gene editing) in engineered immune cells to create and evaluate therapeutic candidates. They will be able to quickly learn and execute workflows, possess strong oral and written communication capabilities, demonstrate excellent collaboration and interpersonal skills, and be adept at problem solving in a fast-paced environment.


  • Expand Orna’s therapeutic pipeline by:
    • Evaluating oRNA constructs to express proteins of interest
    • Evaluating oRNA constructs/formulations in relevant human and animal cells
    • Assist the team in evaluating oRNA constructs/formulations in humanized animal models in-house
  • Execute functional and phenotypic in vitro and in vivo immune assays, such as co-culture, cytotoxicity, flow cytometry and T cell functional assays
  • Work with scientists to execute scientific experiments in a fast-paced environment
  • Generate, interpret, and analyze data with a sense of urgency
  • Assist with solving technical problems in a logical and timely manner
  • Effectively communicate experimental plans and data; present to cross-functional R&D teams
  • Maintain a highly detailed and complete electronic notebook record of performed studies
  • Work in a highly collaborative, cross-functional setting to meet corporate objectives and timelines
  • Contribute to a positive work environment with an entrepreneurial and creative culture


  • Passionate, adaptable research assistant looking to make an impact in a biotech startup environment
  • BS in biology, immunology, or related discipline with 0-1 years relevant laboratory experience in the pharmaceutical or biotechnology industry
  • Experience with tissue culture, human/mouse immune cell culture and functional assays, multi-color flow cytometry, immunoassay development preferred
  • Excellent time management skills and ability to meet tight deadlines
  • Detail oriented and self-motivated, willingness to take on new challenges.
  • Effective written and oral communication skills with experience working in cross-functional setting.

Orna Therapeutics, Inc. is an equal opportunity employer.