PhD Opportunities in RNA Modifications and Their Impact on Disease at Medical University of ViennaMarch 26th, 2025 The Medical University of Vienna is offering exciting PhD opportunities for ambitious scientists interested in the field of RNA modifications and their impact on cellular processes, immune recognition, and disease mechanisms at the Michael Jantsch research group. We are currently seeking motivated candidates to join our dynamic research teams investigating the molecular and physiological effects of RNA recoding and modification. Project 1: Understanding the Regulation and Crosstalk of RNA Modifications RNA modifications play a crucial role in regulating RNA stability, turnover, immunogenicity, and translatability. Our research focuses on adenosine deaminations, which affect the immunogenicity of RNA molecules, as these modifications are recognized by pattern recognition receptors. In particular, adenosine-to-inosine (A-to-I) changes can recode RNAs, altering the proteins they encode. These modifications are essential for normal physiological processes, but when misregulated, they can contribute to various diseases. Key Responsibilities: Investigating the regulation and crosstalk of RNA modifications and their role in immune recognition. Manipulating RNA modifications and analyzing their effects through bioinformatics. Testing the immunogenicity of modified RNAs. Collaborating with interdisciplinary teams to translate basic research into potential therapeutic strategies. Project 2: Physiological Consequences of RNA Recoding in Filamins This project focuses on the physiological consequences of RNA recoding in Filamins, proteins involved in cellular migration, tumor vascularization, and tissue stiffness. We aim to explore how RNA recoding events in Filamins affect their function and contribute to various pathological conditions, including cancer progression. Key Responsibilities: Analyzing the molecular and physiological consequences of RNA recoding events in Filamins. Conducting experiments using transgenic mice and assessing tissue stiffness, vascularization, and cellular migration. Investigating potential therapeutic strategies to manipulate RNA modifications to correct these changes. Skills and Expertise You Will Gain: Expertise in analyzing RNA dynamics and the impact of RNA modifications on cellular processes. Hands-on experience with state-of-the-art sequencing techniques and bioinformatics tools for RNA analysis. Involvement in transgenic animal models and physiological assays. Knowledge of therapeutic strategies to target RNA modifications. Experience in working with interdisciplinary teams in a collaborative research environment. Requirements: Master’s degree in molecular biology, biochemistry, bioinformatics, or a related field. Strong biochemical background, with a preference for candidates with animal physiology training. Advantage: Experience in bioinformatics analysis of sequencing data. Why Join Us? As part of the RNA Biology Program at the Medical University of Vienna, you will have access to cutting-edge resources and collaborate with leading experts in the field. You will participate in weekly seminars, attend an annual RNA symposium, and receive support from our dedicated bioinformatics team. Additionally, you will work closely with labs focused on related topics, ensuring a comprehensive and state-of-the-art education. The Medical University of Vienna is located in one of the world’s most livable cities, providing an enriching environment for both academic and personal growth. Apply Now! We look forward to receiving your application and are excited to see how you can contribute to advancing our understanding of RNA biology. For more details and to apply, please visit: Closing Date: 25.04.2025, 23:55 CET Apply Link: https://oc.meduniwien.ac.at/en/open-phd-positions
|